Sr./Principal HPC System Engineer

About TanemAI

TandemAI is an advanced technology company dedicated to reinventing drug discovery infrastructure. We integrate proprietary AI-driven, high-performance computation with its efficient, large-scale in-house wet lab operations to deliver a turnkey drug discovery solution.

About the Role

The Senior/Principle HPC System Engineer will be responsible for the configuration and operation of our HPC infrastructure and aid in efficient execution of computational workflows. This is a high-growth position, and we expect the candidate to help lead and build the system team as we scale up our computing infrastructure for accelerating drug discovery.

You will:

  • Design, deploy, manage, and maintain our HPC system
  • Install, configure, and modify our infrastructure based on workflow needs, and participate in capacity planning
  • Engage in system administration and monitoring, including security, network, filesystems, and user support
  • Participate in workload performance benchmarking and tuning


  • MS in computer science, engineering, or related technical field with 7+ years of hands-on systems administrator experience (or Ph.D. in one of these fields with 5+ years of experience)
  • Strong knowledge of parallel file systems and storage, networking, security, and HPC resource and job management
  • Hands-on experience with systems administration, monitoring, automation, and scripting/programming
  • Experience in database administration
  • Experience with job schedulers such as SLURM
  • Strong analytical and problem solving skills

Desired Qualifications

  • Knowledge of cloud computing services like AWS and GCP
  • Experience with computational chemistry, molecular dynamics simulations, machine learning, and/or drug discovery
  • Excellent written and oral communication skills, including an ability to explain complex ideas to non-specialists

At TandemAI, we are committed to building a world-class team whose culture is founded on collaboration, intellectual curiosity, trust, and respect. We firmly believe that our exceptional staff will be the key to our success and are committed to high standards and rigorous science. Because of this, we are prepared to offer a competitive salary, stock options, and a wide range of benefits that include healthcare, a 401k, pre-tax commuter benefits, and a flexible work schedule.

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