July 10, 2025
The combined firm will be led by TandemAI co-founder and CEO, Jeff He, MBA. Perpetual Medicines will function as a separate operating entity within TandemAI, and will be headed by Kerry L. Blanchard, MD, PhD, its co-founder, Chairman and Chief Executive Officer; and Ved Srivastava, PhD, Chief Scientific Officer, Financial and other terms were not disclosed.
“This strategic combination is driven by TandemAI’s success in commercializing its physics and AI-based platform for small molecule discovery integrated with wet-lab experimentation and the enormous emerging opportunity afforded by the convergence of high biopharma interest in next generation peptide therapeutics and advances in AI and physics-based methods that are transforming the design and optimization of peptides,” said Lanny Sun, co-founder of Perpetual Medicines and co-founder of TandemAI. “Perpetual has built and validated an outstanding computational/AI platform for peptide drug discovery. The merger positions TandemAI to be a leader in these approaches as well as to explore their application to other modalities.”
“TandemAI was established with a vision to transform drug discovery by enabling broad access to the most advanced AI and physics based computational tools for integrated drug discovery,” said He. “Executing on that vision, in less than four years we have collaborated on small molecule discovery programs with more than 150 partners, including biotechnology firms, multi-national pharmaceutical companies, and academic institutions in the U.S., Europe and China. More than ten client programs are expected to reach clinical trials within the next 12 months. With Perpetual’s integrated computational-synthesis platform and experienced leadership, we have a major opportunity to advance and accelerate peptide drug discovery with partners.”
Mr. He noted that the Perpetual leadership team has been instrumental in the discovery and development of multiple peptide drugs in the U.S., including Byetta® (exantide), Symlin® (pramlintide) and Bydureon® (exantide extended release); marketing approval for Byetta, Bydureon, and Trulicity, and licensing for development of mazdutide in China. Dr. Blanchard has played a key role in four marketed products and the clinical development and approval of more than 30 new medicines in China.
“The commercial and clinical successes of GLP-1, IL-23, and PCSK9 drug classes have greatly expanded the global commercial opportunity for peptide-based therapeutics,” said Dr. Blanchard. “Our AI/computational platform is designed to capitalize on unexplored peptide chemical space to discover new therapeutics with novel attributes. The synergies we expect to realize through the merger with TandemAI, will greatly accelerate these efforts.”
He noted that since its founding in 2023, Perpetual has built and validated its AI/computational platform and automated peptide synthesis technology; achieved preclinical, in vivo proof of concept with its lead program to develop orally available cyclic peptides; and entered a strategic peptide discovery collaboration with a major U.S. venture capital firm.
